Substance Abuse in Clozapine-Treated Schizophrenic Patients
نویسندگان
چکیده
منابع مشابه
Clozapine treatment in patients with prior substance abuse.
OBJECTIVE This study examined outcomes following discharge on clozapine for treatment-resistant schizophrenia patients with and without diagnosed substance abuse histories. METHODS Those discharged on clozapine from a research unit between April 1991 and March 1996 were followed with respect to hospitalization status. Of the treatment-resistant patients with schizophrenia, 19 were diagnosed a...
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Several studies suggest a high comorbidity of substance abuse and schizophrenia, associated with higher frequency of relapse, more positive symptoms and depression, cognitive impairment, poorer outcome and treatment response. A high incidence of substance abuse is also observed in first-episode patients. Among patients with substance abuse, the onset precedes the onset of psychosis of several y...
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The risk of potentially life threatening idiosyncratic reactions, limited the use of clozapine therapy, in the treatment refractory schizophrenia. The present study aims to investigate the neutrophil cytotoxicity in the clozapine treated schizophrenic patients, as it is still prescribed frequently for psychiatric patients in Pakistan. The assessment was focused on the hematological and absolute...
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Approximately 40%-70% of neuroleptic-resistant schizophrenic patients are nonresponders even to clozapine. Several clozapine augmentation strategies have come into clinical practice, although often without evidence-based support. This study aims to critically review all the reported case studies regarding the efficacy and safety of adjunctive agents in clozapine-resistant schizophrenic or schiz...
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Treatment resistance to clozapine often leads to antipsychotic combinations. Well-designed trials evaluated the add-on of several atypical antipsychotics, but the augmentation with paliperidone, the active metabolite of risperidone, has never been evaluated. Treatment of four cases resulted in a decrease of the PANSS-positive subscale, the mean initial clozapine dose could be lowered, mean prol...
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ژورنال
عنوان ژورنال: The Journal of Neuropsychiatry and Clinical Neurosciences
سال: 1997
ISSN: 0895-0172,1545-7222
DOI: 10.1176/jnp.9.4.626-a